Wide receivers DeVonta Smith (hamstring) and Dontayvion Wicks (ankle) also sat out. ProFootballTalk says both are on track to miss a third straight game.
What is confirmed
Barkley, Smith and Wicks were all listed as did not practice on Wednesday's report. Linebacker Jihaad Campbell, defensive back Michael Carter, receiver Britain Covey and cornerback Jonathan Jones also missed practice. Tight end Dallas Goedert (knee) was a full participant.
Barkley has been managing these injuries for two weeks. He missed the first two practices last week, got limited work Friday and then played 22 snaps Sunday night against Washington. The week before, he played 10 snaps against Dallas.
What it means
The pattern matters more than one missed Wednesday. Barkley has played on Sunday after sitting early in the week, so this is not a reason to panic. It is a reason to doubt his workload. Ten and 22 snaps are backup numbers, and a back who sees that little work is hard to trust in a lineup no matter how much he costs against your cap.
The offense around him is also shaky. Philadelphia is turning to Joe Milton III at quarterback after Tanner McKee went 0-3 as the starter, and the team has played without Smith for two games. Thin receiver depth and a new quarterback make it harder for any Eagles skill player to put up big numbers.