New England will face the Bears without Alijah Vera-Tucker and Ben Brown, while A.J. Brown carries no injury designation. Chicago is without Kyle Monangai again, leaving D'Andre Swift as the lead back for the 8:15 p.m. ET kickoff on Prime Video.
Underdog NFL reported Wednesday that Jaxon Smith-Njigba is not listed on Seattle's Week 6 injury report after limited ankle work earlier in the week. Denver hosts the Seahawks at 8:15 p.m. ET on Prime Video without safety Talanoa Hufanga and cornerback Pat Surtain II.
Week 6 opens Thursday with Seahawks at Broncos on Prime Video and ends Monday with Commanders at 49ers on ESPN and ABC. The Bengals, Lions, Dolphins and Vikings are on bye.
Buffalo lists DJ Moore as questionable with a shoulder injury and called up Trent Sherfield from the practice squad before Monday night's game in Los Angeles. Joshua Palmer and Ed Oliver are out, while the Rams' Quentin Lake is questionable.
Lamar Jackson is out with his ankle injury, so Tyler Huntley gets the Sunday night start against the Falcons. Zay Flowers and Marlon Humphrey are questionable but expected to play, while Atlanta loses Za'Darius Smith.
Most of Sunday's game-time decisions went the way fantasy managers hoped, with four key questionable players active. Ladd McConkey's foot is the big call left for the 4 PM window.
Tampa Bay's undrafted rookie makes his second NFL start Thursday night at the Cowboys, and Baker Mayfield is ruled out. Dallas gets left guard Tyler Smith back from injured reserve for the 8:15 p.m. ET kick on Prime Video.