There is no NFL game tonight, Friday, Nov. 6. Thursday Night Football was Thursday, Nov. 5. The next slate begins Sunday, Nov. 8, with Cincinnati against Atlanta in Madrid at 9:30 a.m. ET on NFL Network, according to the Falcons' viewing guide.
San Francisco hosts Las Vegas on Sunday at 4:25 p.m. ET on FOX. The 49ers' current viewing guide lists 1:25 p.m. Pacific, which is 4:25 p.m. Eastern.
McCaffrey's clearance helps an offense missing several receivers. Mike Evans (ribs/Achilles), Deebo Samuel (hamstring) and Christian Kirk (knee) are out, while Demarcus Robinson (ankle) is questionable. Those absences can raise his receiving role, but target count is still a game-day question. Do not simply reassign the missing receivers' volume to him on paper.
For owners eyeing a replacement signing, Friday's full practice removes the immediate reason to spend for a back solely to cover McCaffrey this weekend. Keep a healthy alternative on the roster if you have one. The late kickoff matters if anything changes after your early-game options have already played.