Christian McCaffrey and Mike Evans miss 49ers practice Wednesday

Christian McCaffrey and Mike Evans both sat out the San Francisco 49ers' first practice out of the Week 8 bye on Wednesday, NFL Network's Mike Garafolo and Ian Rapoport said. McCaffrey is dealing with a hamstring injury and Evans with his Achilles. Coach Kyle Shanahan said McCaffrey is "not going today but hopefully a chance" Thursday, according to the Bay Area News Group via RotoWire.

What's confirmed. Both players were held out Wednesday. Deebo Samuel (hamstring) also did not practice, per Underdog NFL. Edge rusher Nick Bosa (calf) returned on a limited basis. San Francisco hosts the Las Vegas Raiders on Sunday at 4:25 PM ET.

The injury history. McCaffrey has had the hamstring issue since he left the Week 7 game in Atlanta. The team later called it a mild strain and said it expected him to be ready after the bye. Evans aggravated a right Achilles injury in Week 6 against Washington and sat out the loss in Atlanta. The expectation was also that he would return after the bye.

Why it matters for RSO. One Wednesday DNP coming off a week of rest is not a ruling. It does push both players into the questionable range until the 49ers show more. McCaffrey is the higher-stakes case. He is a weekly starter for anyone who rosters him, and a hamstring that lingers past a bye is worth taking seriously for a running back his age. For Evans, an Achilles that keeps flaring is the bigger long-term concern for a veteran receiver, even if he plays Sunday.

What to do now. If you roster McCaffrey, make sure your handcuff plan is set before waivers clear, and keep an eye on who gets the work if he sits. Evans owners should line up a bench receiver with a Sunday or Monday kickoff so they have a fallback for the 4:25 PM window. Don't sell either one at a discount off one missed practice.

What to watch next. Thursday's practice report is the key one. A limited session for McCaffrey would match Shanahan's hope. Another full absence would make Friday's game status the real deadline. Track Samuel too, since three missing starters would change how San Francisco spreads the ball against Las Vegas.