Here is what is confirmed. The Ravens listed Jackson as a full participant, and Adam Schefter and ESPN's Jamison Hensley both relayed the designation. Jackson hasn't played since Week 4. Baltimore downgraded him to out last Saturday before the Bengals game, so this is the first clear sign that he's on track to return.
What is not confirmed yet is a game status. Wednesday reports often run on estimates or lighter work, and the Ravens won't issue designations until Friday. Two more full days would make Sunday very likely. A step back to limited on Thursday would put things back in doubt.
The rest of the Ravens report is worse news. Four starters did not practice, according to Hensley: safety Kyle Hamilton, guard Vega Ioane, linebacker Roquan Smith and safety Jaylinn Hawkins. Hamilton was wearing a large brace on his right knee. That matters for anyone starting Bills players this week, because Buffalo could face a thinner Baltimore defense. Rookie running back Adam Randall was also back on the practice field.
For RSO owners, the move with Jackson is to plan on starting him while keeping your backup in place through Friday. If you've been carrying a second quarterback only to cover his absence, don't drop that player yet. Wait until the Ravens post a final status, ideally with no designation, and make the cut then. Anyone who tried to buy Jackson low during the injury has probably missed the cheapest price, but a manager in a lost season may still take a fair offer before Sunday.
His contract value doesn't change. An ankle that kept him out for weeks is a fair reason to lean on your backup in a close matchup until he plays a full game without trouble.