
Sunday NFL preview: London opens Week 5, 49ers–Seahawks lead late window
Philadelphia’s injuries shape the London opener; Huntley starts for Baltimore in Atlanta on Sunday night.
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Philadelphia’s injuries shape the London opener; Huntley starts for Baltimore in Atlanta on Sunday night.

Saturday brought a clearer read on where Marvin Harrison Jr. is headed, though no deal is done. Pittsburgh and New England also lost receivers to injured reserve before Week 5.

Houston adds two defenders to its active roster before a meeting of winless AFC South teams; both still carry questionable game designations.

Three questionable starters will be decided on the inactive lists 90 minutes before kickoff. The London game at 9:30 a.m. ET means Eagles lineups have to be set early.

New England moved wide receiver Mack Hollins to injured reserve Saturday, a day after ruling him out against the Raiders. He will miss at least four games, leaving Romeo Doubs and a young group to carry the receiver snaps.

Green Bay moved running back Chris Brooks to injured reserve Saturday afternoon, a day before its home game against Chicago. The move keeps him out at least four games and leaves Kaleb Johnson, MarShawn Lloyd and Pierre Strong Jr. to share the backfield.

Pittsburgh is placing Pittman on short-term IR after he aggravated a left foot injury in practice this week, according to ESPN. The move keeps him out at least four games and opens more snaps for Roman Wilson and rookie Germie Bernard.

Head coach Joe Brady said Saturday that Palmer will miss Week 5 after getting hurt in Friday's practice. Rookie Skyler Bell will make his NFL debut and pick up many of Palmer's snaps.

New reporting describes Baltimore’s medical visit before the deal; Jurgens’ playing clearance remains a separate question.

Indianapolis downgraded Slayton to out on Saturday after he hurt his knee in Friday's practice. The Colts also elevated Nick Westbrook-Ikhine and put Arden Key on injured reserve.

Arizona told Harrison he will be inactive against Detroit while a trade is finished after Sunday's games. Houston is in the mix, and the Colts are not involved.

McKee and Payton remain behind Hurts as injuries create roster needs at center and running back.

Philadelphia, Baltimore, Washington and Chicago all lost key fantasy pieces on Friday's final injury reports. The Chargers and Raiders receiver rooms also thinned out before Sunday.

CeeDee Lamb and Tyler Guyton practiced fully Wednesday; Joey Porter Jr. was limited with an ankle injury.

Dallas will use its break before Green Bay to reassess playing time and scheme after a 24–16 loss to Tampa Bay.

Miami was awarded the former Commanders sixth-round pick a day after Washington waived him. Allen is a deep-league stash for now, not a Week 5 start.

Denver's receiver will miss at least four games after Friday's move. The Broncos signed Lil'Jordan Humphrey to the active roster to take his spot.

Los Angeles will face Denver on Sunday without Johnston or Brenen Thompson at receiver. Ladd McConkey is questionable with his foot injury, which leaves the receiver room thin.

Las Vegas will play at New England without Nailor (concussion) and Dont'e Thornton Jr. (hamstring). Jeanty missed Friday practice with an ankle and foot injury but will travel and try to play.

New England will be without Hollins on Sunday, with A.J. Brown already on injured reserve. The Patriots also ruled out four cornerbacks, including starters Christian Gonzalez and Carlton Davis III.

Philadelphia will face Jacksonville on Sunday without its lead back and its No. 2 receiver, both out with hamstring injuries. Will Shipley moves to the front of a thin backfield, and Dallas Goedert returns at tight end.

Cincinnati’s top receivers remain uncertain for Sunday. Higgins is questionable, while Chase still needs concussion clearance.

Washington’s quarterback completed a full practice week and will start Sunday while wearing a brace on his left arm.

Jesse Minter ruled Jackson out Friday after the quarterback missed every practice this week with an ankle injury. Tyler Huntley will start against the Falcons.