What is confirmed
The Colts ruled out three players for Sunday: Warren (groin), cornerback Sauce Gardner (calf) and wide receiver Anthony Gould (concussion). Warren did not practice Thursday or Friday, per The Indianapolis Star's Nathan Brown and RotoWire.
This is the second game in a row Warren will miss. He was listed as questionable for last Sunday's game against Tennessee and ended up inactive with the same groin injury.
What we don't know yet
The Colts have not given a timeline beyond this week, and there is no sign of an injured reserve move. A missed week of practice followed by a second straight absence suggests this is more than a one-week problem, but the team has not said that.
Why it matters for RSO owners
Warren was the 14th overall pick in 2025 and signed a four-year, $20.96 million rookie deal in May of that year, per RotoWire. That cost-controlled contract runs through the 2028 season, so his dynasty value holds even if this drags on for a few more weeks. Short term, owners lose their tight end again.
Will Mallory should lead the Colts' tight ends in pass routes Sunday, with Mo Alie-Cox and Drew Ogletree also involved, per RotoWire. None of the three is a reliable weekly starter, and the targets Warren usually draws are more likely to go to Michael Pittman and Josh Downs.
