What is confirmed
Slayton will not play in Week 5. He showed up on the Colts' practice report for the first time this week on Friday with the knee injury and was listed as questionable that afternoon. Saturday's downgrade removes any game-time decision.
He has yet to make his Colts debut. Indianapolis signed him on Sept. 22, and he has not played in a game since then.
The Colts made two more moves with the announcement. They elevated wide receiver Nick Westbrook-Ikhine from the practice squad for Sunday, and they placed defensive end Arden Key on injured reserve with a hamstring injury, which keeps him out at least the next four games. Key had already been ruled out for this week.
Who plays instead
Keenan Allen is questionable with a groin injury but was a full participant in Friday's practice, which points toward him playing. Ashton Dulin was ruled out on Friday. That leaves Westbrook-Ikhine as the depth piece the team added specifically for this game.
No timeline has been given for Slayton beyond this week. The team has not said whether the knee is a short-term issue or something longer.