What is confirmed
Rice will not play in Week 7. Reid also ruled out running back Brashard Smith, and right tackle Jaylon Moore, who has a concussion, is likely to be listed as out as well.
Rice did not practice Wednesday, Thursday or Friday, per RotoWire and The Kansas City Star. This is the second straight game he will miss after Reid ruled him out of the Week 6 game against the Chargers with the same hamstring and knee issue.
What is still unclear
The Chiefs have not given a timeline for his return, and there is no injured reserve move. Two straight weeks without a single practice is the part that should worry owners. Until he gets back on the field in some form, there is no clear path to a Week 8 return.
Why it matters for RSO owners
Xavier Worthy steps in as the Chiefs' top wide receiver again, per RotoWire, and should see the most targets on Sunday. Worthy owners can start him with more confidence, even in a road game at Seattle.
For Rice owners, the issue is the calendar. Each missed week costs you a starter you are paying for, and you get no production back for that cap space. His long-term value in dynasty formats has not changed, since this is a soft-tissue injury and not a major structural one.