Harris has not practiced since leaving the Week 5 loss to Denver with the hamstring injury. Coach Jim Harbaugh called him week to week earlier in the week, and the final report closes the door for Arrowhead. Fantasy managers who started him in weekly formats should sit him; the Chargers are on a bye in Week 7, so the next chance is Week 8.
James has been dealing with the hamstring across recent weeks and is out again. That removes the centerpiece of Los Angeles' secondary against Patrick Mahomes. Jackson is also out with a hamstring, so the corner room is thin even with Elijah Molden cleared.
Alt's neck issue kept him out of practice all week. Losing the left tackle raises protection questions for Justin Herbert against a Chiefs pass rush, and Awosika's fibula absence further squeezes the interior line.
The clearer news for pass catchers is who came off the report. Ladd McConkey (foot) and Quentin Johnston (chest) both practiced fully Friday and carry no game designation. Marquez Valdes-Scantling (rib) and Charlie Kolar (forearm) are also off the report. KeAndre Lambert-Smith (hamstring) remains questionable after the club opened his 21-day practice window Wednesday.
Six Chargers are questionable: linebacker Daiyan Henley (knee), edge Bud Dupree (neck), defensive linemen Jamaree Caldwell (knee) and Dalvin Tomlinson (hamstring), receiver Brenen Thompson (quad), and Lambert-Smith. Corner Rodney Shelley (hamstring) is doubtful.
