To fill the roster spot, Denver signed receiver Lil'Jordan Humphrey to the active roster. The team also signed defensive back Ugo Amadi to the practice squad.
Bryant had carved out a steady role through the first four weeks. He has nine catches on 12 targets for 133 yards and one touchdown, per ESPN's game logs. His best day came in Week 3 against the Rams, when he caught both of his targets for 44 yards and a score. He added three catches for 47 yards at San Francisco in Week 4, so the injury hits just as his usage was trending in the right direction.
The timing matters for Denver's offense. The Broncos visit the Chargers on Sunday, and the four-game minimum means Bryant cannot return before mid-November at the earliest. Somebody has to absorb his snaps and his 12 targets. Humphrey arrives as depth, so the receivers already in the rotation are the more likely beneficiaries.
For fantasy, Bryant was a bench stash in most leagues and a bye-week fill-in for deeper rosters. His absence nudges the Denver passing game toward fewer, more concentrated targets, which helps the top options more than it creates a new starter.
What RSO owners should do now: Move Bryant to an IR slot if your league has one, and hold him in dynasty formats, since this is a short-term placement. In redraft or shallow leagues, he can be cut if you need the roster spot. Humphrey is not a priority add.